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Phylogenetic Differential Expression

Functions to test for differential expression using moderated phylogenetic linear regression.

phyloDE-package phyloDE
The phyloDE Package for Differential Expression Analysis
phylolmFit()
Phylogenetic Linear Model for Gene Expression Analysis
phylogeneticCorrelations()
Phylogenetic Correlation using a Consensus Tree

S4 Classes

Classes containing the result of a fit and associated helper functions.

PhyloMArrayLM-class
Class PhyloMArrayLM
ConsensusTreeModel-class
Class ConsensusTreeModel
getParameters() plotParameters() show(<PhyloMArrayLM>) show(<ConsensusTreeModel>) logLikelihood() consensusTree()
Methods for classes PhyloMArrayLM and ConsensusTreeModel

Helper Functions

Function to pre-process the tree or the data.

phyHeatmap()
Heatmap with Phylogeny Structured Columns
addReplicatesOnTree()
Add replicates to a tree
lengthNormalizeRNASeq()
Normalize RNASeq count data using gene lengths
rhoFromAlpha() alphaFromRho()
Compute rho parameter
getBoundsSelectionStrength()
Get Bounds on alpha for an OU
getMinError()
Get Lower Bound on sigma2_error

Dataset

Crayfish dataset

crayfish
Crayfish RNA-Seq dataset